Biochemistry
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Medium-sized protein language models perform well at transfer learning on realistic datasets
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Acetylation of RORβ by histone acetyltransferase p300 and deacetylation by SIRT1 modulates receptor stability, turnover and transcriptional activity
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Computational enzyme design by catalytic motif scaffolding
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Allosteric modulation of the Lon protease by effector binding and local charges
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Mechanistic Studies of Small Molecule Ligands Selective to RNA Single G Bulges
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The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling
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Structure of the human CTF18−RFC clamp loader bound to PCNA
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Protonation/deprotonation-driven switch for the redox stability of low-potential [4Fe-4S] ferredoxin
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Interactions with multiple inner kinetochore proteins determine mitotic localization of FACT
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Daptomycin forms a stable complex with phosphatidylglycerol for selective uptake to bacterial membrane
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