Biochemistry
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The cryo-EM structure of ASK1 reveals an asymmetric architecture allosterically modulated by TRX1
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Structure-guided mutagenesis of OSCAs reveals differential activation to mechanical stimuli
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Structural mechanisms for VMAT2 inhibition by tetrabenazine
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The non–muscle actinopathy–associated mutation E334Q in cytoskeletal γ– actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins
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DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks
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Structural basis of closed groove scrambling by a TMEM16 protein
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Beyond the Active Site: The addition of a remote loop reveals a new complex biological function for chitinase enzymes
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The catalytic mechanism of the RNA methyltransferase METTL3
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Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens
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Rapid, DNA-induced interface swapping by DNA gyrase
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