Higher molecular weight alpha-synuclein oligomers are increased in brain cytosol from dementia with Lewy bodies

  1. Emil Gregersen
  2. Mia R. Antorini
  3. Lasse Reimer
  4. Ludovica Zaccagnini
  5. Dennis Selkoe
  6. Tim Bartels
  7. Poul Henning Jensen
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Abstract

The size-distribution of α-synuclein oligomers in brain cytosol from dementia with Lewy bodies (DLB) and control cases was investigated by combining size-exclusion chromatography and an aggregate specific MJFR14-6-4-2 ELISA. The oligomers in DLB peaked at 340 kDa and extended up to 2000 kDa. In controls, oligomers were smaller. Immunoblotting revealed the existence of pools of oligomers with different sensitivity to denaturation.

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