Effects Of Gongronema Latifolium (Benth.) Leaf Extract on Cardiac Glutathione and Dopamine Antioxidant Systems

This study investigates the effects of Gongronema latifolium methanolic leaf extract (GLL) on antioxidant enzyme activities and dopamine levels in cardiac tissue. Female Wistar rats (150 ± 30g) were divided into four groups, one control group and three treatment groups (treated with GLL at doses of 250, 500, and 1000 mg/kg for 28 days). The animals were sacrificed after 28 days and the hearts were excised for biochemical analysis (reduced glutathione (GSH) level, glutathione peroxidase (GPx) activity, glutathione S-transferase (GST) activity, superoxide dismutase (SOD) activity, and dopamine level). Results showed dose-dependent modulation of these parameters. GSH and dopamine levels significantly increased at higher doses, enhancing antioxidative defences and potentially supporting cardiovascular function. GPx activity showed sustained elevation across doses, while SOD activity showed a pronounced dose-independent increase, highlighting robust antioxidant effects. GST activity, however, peaked at moderate doses (250 mg/kg), suggesting a biphasic response. These findings show the potential of GLL as a cardioprotective agent. This study contributes to the understanding of its role in mitigating oxidative stress and improving cardiovascular health. Higher doses could overwhelm detoxification pathways, showcasing the need for well-optimized dosages. Future research should explore the molecular pathways underlying these effects and assess GLL’s therapeutic potential against cardiovascular disorders.