Bioactive Glass Preloaded with Antibiotics for Long-Term Delivery Localized Drug Release Exhibiting Inherent Antimicrobial Activity

This study aimed to design a new drug delivery system for long-term drug release for the treatment of various diseases. Bioactive glass preloaded with vancomycin (BG-V), synthesized without any thermal treatment, was designed to load higher percentages of the drug and release it slowly over time. In this study, BG-V was synthesized using a solution containing vancomycin to allow the glass to form around it. BG-V was then left to dry at room temperature to form a white powder with vancomycin trapped in the structure. The successful synthesis of BG-V was confirmed by X-ray diffraction, Fourier-transform infrared spectroscopy, scanning emission scanning microscopy, and nitrogen adsorption-desorption analysis. The results showed that BG-V was successfully developed using FTIR, showing vancomycin within the BG-V structure. After the drug release, BG-V shows great bioactivity as shown by XRD and bacterial studies.