Spinal electrophysiology reveals frequency-specific spatial patterns of neural activity and corticospinal coherence during pincer-grip

  1. Prabhav Mehra
  2. Saroj Bista
  3. Marjorie Metzger
  4. Eileen R. Giglia
  5. Serena Plaitano
  6. Leah Nash
  7. Éanna Mac Domhnaill
  8. Peter Bede
  9. Muthuraman Muthuraman
  10. Orla Hardiman
  11. Madeleine Lowery
  12. Bahman Nasseroleslami
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Abstract

Background

Neural dynamics within sensory-motor networks involved in motor control exhibit well-established frequency-dependent patterns of cortical activity. In contrast, corresponding neural patterns of spinal cord activity remain poorly understood. As an active functional part of motor control, characterising spinal cord activity is essential for understanding sensorimotor function. High-density electrospinography presents a novel technique to assess spinal neural dynamics by non-invasively recording task-relevant electrical activity.

Objective

To non-invasively investigate spatio-spectral patterns of task-related spinal activity and its functional connectivity with cortical regions during isometric pincer-grip contraction.

Methodology

Here, we simultaneously recorded 128-channel electroencephalography (EEG), 64-channel electrospinography (ESG), and two bipolar electromyography (EMG) signals during an isometric pincer-grip task. Frequency-specific spatial patterns of spinal activity and cortico-spinal connectivity were evaluated by calculating task-related ESG power and cortico-spinal coherence between ESG and EEG signals during the isometric hold.

Results

Distinct frequency-specific spatial patterns of spinal activity were observed at lower cervical levels during sustained hold, with significant activation over the ipsilateral anterolateral region. In the beta band, task-related spinal activity was significantly ipsilateralised, and exhibited significant cortico-spinal connectivity between contralateral motor cortex and ipsi-anterolateral spinal region.

Conclusions

This first-of-its-kind application of HD non-invasive spinal electrophysiology revealed that the spinal cord exhibits distinct frequency-specific spatial activation and cortical connectivity patterns during pincer-grip sustained hold. Specifically, the ipsi-anterolateral spinal region demonstrated high task-relevance, potentially indicating anterior horn activity and its connectivity with motor cortex. Furthermore, beta-band activation was observed as a key signature during sustained hold, further underpinning its relevance during motor control.

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