Mood computational mechanisms underlying increased risk behavior in adolescent suicidal patients

Suicidal thoughts and behaviors (STB) rank among the foremost causes of death globally. While literature consistently highlights increased risk behavior in individuals with STB and identifies mood issues as central to STB, the precise cognitive and affective computational mechanisms driving this increased risky behavior remain elusive. Here, we asked 83 adolescent inpatients with affective disorders, where 58 patients with STB (S⁺) and 25 without STB (S⁻), and 118 gender/age-matched healthy control (HC) to make decisions between certain vs. gamble option with momentary mood ratings. Choice data analyses revealed more risk behavior in S⁺compared to S⁻and HC. Using a prospect theory model enhanced with approach-avoidance parameters revealed that this rise in risky behavior resulted only from a heightened approach parameter in S⁺. Furthermore, approach strength mediated the rise in gambling choices with STB severity. Altogether, model-based choice data analysis indicated dysfunction in the approach system in S⁺individuals, leading to greater propensity for gambling in favorable outcomes regardless the lotteries expected value. Additionally, mood model-based analyses revealed reduced sensitivity to certain rewards in S⁺compared to S⁻and HC. Importantly, these computational markers generalized to healthy population (n□ = □ 747). In S⁺, mood sensitivity to certain reward was negatively correlated with gambling, offering a mood computational account for increased risk behavior in STB. These findings remained significant even after adjusting for demographic, clinical, and medication-related variables. Overall, our study uncovers the cognitive and affective mechanisms contributing to increased risk behavior in STB, with significant implications for suicide prevention.