Serological responses and six-month trajectories to COVID-19 Comirnaty and Spikevax booster vaccine, September 2021 to January 2022, London, United Kingdom

  1. Georgina Ireland
  2. Heather Whitaker
  3. Shamez N Ladhani
  4. Frances Baawuah
  5. Sathyvani Subbarao
  6. Suzanne Elgohari
  7. Alexandra Smith
  8. Michelle O’Brien
  9. Corinne Whillock
  10. Oliver Martin
  11. Paul Moss
  12. Mary E Ramsay
  13. Gayatri Amirthalingam
  14. Kevin E Brown
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Abstract

In contrast to the increasing levels of high avidity S antibody measured by the Roche assay in the first 6 months following natural infection, marked waning is seen post 2 or 3 doses of vaccine. Although the kinetics differ between those with vaccine-induced immunity compared to those infected prior to vaccination (hybrid immunity), waning rates appear to be similar following 2 or 3 doses of vaccine. These data should allow countries to optimise the timing of future doses of vaccine.

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